![]() ![]() 9– 11 A composite score provides an attractive advantage over 30 indicators by reducing overfitting risk in small datasets and limiting computational requirements in large datasets. Despite several studies demonstrating Elix-hauser's comorbidity system to be statistically superior for predicting various outcomes, 5– 8 the Charlson comorbidity index continues to be used. 3 While interpreting 30 indicators and modeling numerous interactions can be difficult, 4 Elixhauser et al 2 recommended against a single score. ![]() 1 Two popular methods are the Elixhauser comorbidity system, 2 a set of 30 comorbidity indicators, and the Charlson co-morbidity index-a composite score summarized by a weighted combination of 17 comorbidities. Observational studies using administrative data require proper comorbidity adjustment to reduce bias.
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